Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresse...

Full description

Bibliographic Details
Main Authors: Svitlana Tyekucheva, Michaela Bowden, Clyde Bango, Francesca Giunchi, Ying Huang, Chensheng Zhou, Arrigo Bondi, Rosina Lis, Mieke Van Hemelrijck, Ove Andrén, Sven-Olof Andersson, R. William Watson, Stephen Pennington, Stephen P. Finn, Neil E. Martin, Meir J. Stampfer, Giovanni Parmigiani, Kathryn L. Penney, Michelangelo Fiorentino, Lorelei A. Mucci, Massimo Loda
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00460-4
id doaj-f7c7f334fc234cc396a3e044b2046d32
record_format Article
spelling doaj-f7c7f334fc234cc396a3e044b2046d322021-05-11T07:20:32ZengNature Publishing GroupNature Communications2041-17232017-09-018111010.1038/s41467-017-00460-4Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancerSvitlana Tyekucheva0Michaela Bowden1Clyde Bango2Francesca Giunchi3Ying Huang4Chensheng Zhou5Arrigo Bondi6Rosina Lis7Mieke Van Hemelrijck8Ove Andrén9Sven-Olof Andersson10R. William Watson11Stephen Pennington12Stephen P. Finn13Neil E. Martin14Meir J. Stampfer15Giovanni Parmigiani16Kathryn L. Penney17Michelangelo Fiorentino18Lorelei A. Mucci19Massimo Loda20Department of Biostatistics and Computational Biology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Oncologic Pathology, Dana-Farber Cancer InstituteDepartment of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of BolognaDepartment of Oncologic Pathology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Surgical Pathology, Maggiore HospitalDepartment of Medical Oncology, Dana-Farber Cancer InstituteKing’s College London, Division of Cancer Studies, Translational Oncology & Urology Research, Guy’s HospitalDepartment of Urology, School of Health and Medical Sciences, Örebro University HospitalDepartment of Urology, School of Health and Medical Sciences, Örebro University HospitalSchool of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College DublinSchool of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College DublinDepartment of Histopathology and Morbid Anatomy, School of Medicine, Trinity College DublinDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer InstituteChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of BolognaChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Oncologic Pathology, Dana-Farber Cancer InstituteStromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.https://doi.org/10.1038/s41467-017-00460-4
collection DOAJ
language English
format Article
sources DOAJ
author Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
spellingShingle Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
Nature Communications
author_facet Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
author_sort Svitlana Tyekucheva
title Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_short Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_full Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_fullStr Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_full_unstemmed Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_sort stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.
url https://doi.org/10.1038/s41467-017-00460-4
work_keys_str_mv AT svitlanatyekucheva stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT michaelabowden stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT clydebango stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT francescagiunchi stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT yinghuang stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT chenshengzhou stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT arrigobondi stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT rosinalis stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT miekevanhemelrijck stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT oveandren stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT svenolofandersson stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT rwilliamwatson stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT stephenpennington stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT stephenpfinn stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT neilemartin stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT meirjstampfer stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT giovanniparmigiani stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT kathrynlpenney stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT michelangelofiorentino stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT loreleiamucci stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
AT massimoloda stromalandepithelialtranscriptionalmapofinitiationprogressionandmetastaticpotentialofhumanprostatecancer
_version_ 1721452418683633664

Similar Items