Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling

Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling

The Bacillus anthracis Edema Toxin (ET), composed of a Protective Antigen (PA) and the Edema Factor (EF), is a cellular adenylate cyclase that alters host responses by elevating cyclic adenosine monophosphate (cAMP) to supraphysiologic levels. However, the role of ET in systemic anthrax is unclear....

Full description

Bibliographic Details
Main Authors: Zijian Pan, Eric K. Dumas, Christina Lawrence, Lance Pate, Sherri Longobardi, Xiaodong Wang, Judith A. James, Susan Kovats, A. Darise Farris
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Bacillus anthracis
Edema Toxin
macrophage
efferocytosis
Online Access:http://www.mdpi.com/1422-0067/20/5/1167

Internet

http://www.mdpi.com/1422-0067/20/5/1167

Similar Items