Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro
Glaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, wide...
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Frontiers Media S.A.
2017-09-01
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00285/full |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng-Juan Gao Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Ping Xu Ping Xu Ping Xu Ping Xu Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Rong Zhang Rong Zhang Rong Zhang Rong Zhang Yun Cheng Yun Cheng Yun Cheng Yun Cheng Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Wan-Jing Huang Min Wang Jun-Yi Chen Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu |
spellingShingle |
Feng-Juan Gao Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Ping Xu Ping Xu Ping Xu Ping Xu Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Rong Zhang Rong Zhang Rong Zhang Rong Zhang Yun Cheng Yun Cheng Yun Cheng Yun Cheng Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Wan-Jing Huang Min Wang Jun-Yi Chen Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro Frontiers in Molecular Neuroscience quercetin retinal ganglion cells glaucoma apoptosis mitochondria neuroprotection |
author_facet |
Feng-Juan Gao Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Sheng-Hai Zhang Ping Xu Ping Xu Ping Xu Ping Xu Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Bo-Qi Yang Rong Zhang Rong Zhang Rong Zhang Rong Zhang Yun Cheng Yun Cheng Yun Cheng Yun Cheng Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Xu-Jiao Zhou Wan-Jing Huang Min Wang Jun-Yi Chen Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Xing-Huai Sun Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu Ji-Hong Wu |
author_sort |
Feng-Juan Gao |
title |
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro |
title_short |
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro |
title_full |
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro |
title_fullStr |
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro |
title_full_unstemmed |
Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro |
title_sort |
quercetin declines apoptosis, ameliorates mitochondrial function and improves retinal ganglion cell survival and function in in vivo model of glaucoma in rat and retinal ganglion cell culture in vitro |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Neuroscience |
issn |
1662-5099 |
publishDate |
2017-09-01 |
description |
Glaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, widely distributed in fruits and vegetables. Mounting evidence suggests that Qcn has numerous neuroprotective effects. However, whether Qcn exerts neuroprotective effects on RGC in glaucoma is poorly understood. In this study, we investigated the protective effect of Qcn against RGC damage in a rat chronic ocular hypertension (COHT) model invivo and hypoxia-induced primary cultured RGC damage in vitro, and we further explored the underlying neuroprotective mechanisms. We found that Qcn not only improved RGC survival and function from a very early stage of COHT invivo, it promoted the survival of hypoxia-treated primary cultured RGCs invitro via ameliorating mitochondrial function and preventing mitochondria-mediated apoptosis. Our findings suggest that Qcn has direct protective effects on RGCs that are independent of lowering the intraocular pressure (IOP). Qcn may be a promising therapeutic agent for improving RGC survival and function in glaucomatous neurodegeneration. |
topic |
quercetin retinal ganglion cells glaucoma apoptosis mitochondria neuroprotection |
url |
http://journal.frontiersin.org/article/10.3389/fnmol.2017.00285/full |
work_keys_str_mv |
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doaj-f7d208618a354f8e823196b71d32f64e2020-11-24T22:52:04ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-09-011010.3389/fnmol.2017.00285291573Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In VitroFeng-Juan Gao0Sheng-Hai Zhang1Sheng-Hai Zhang2Sheng-Hai Zhang3Sheng-Hai Zhang4Ping Xu5Ping Xu6Ping Xu7Ping Xu8Bo-Qi Yang9Bo-Qi Yang10Bo-Qi Yang11Bo-Qi Yang12Rong Zhang13Rong Zhang14Rong Zhang15Rong Zhang16Yun Cheng17Yun Cheng18Yun Cheng19Yun Cheng20Xu-Jiao Zhou21Xu-Jiao Zhou22Xu-Jiao Zhou23Xu-Jiao Zhou24Wan-Jing Huang25Min Wang26Jun-Yi Chen27Xing-Huai Sun28Xing-Huai Sun29Xing-Huai Sun30Xing-Huai Sun31Ji-Hong Wu32Ji-Hong Wu33Ji-Hong Wu34Ji-Hong Wu35Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaEye Institute, Eye and ENT Hospital, College of Medicine, Fudan UniversityShanghai, ChinaState Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan UniversityShanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality,Shanghai, ChinaKey Laboratory of Myopia, Ministry of HealthShanghai, ChinaGlaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, widely distributed in fruits and vegetables. Mounting evidence suggests that Qcn has numerous neuroprotective effects. However, whether Qcn exerts neuroprotective effects on RGC in glaucoma is poorly understood. In this study, we investigated the protective effect of Qcn against RGC damage in a rat chronic ocular hypertension (COHT) model invivo and hypoxia-induced primary cultured RGC damage in vitro, and we further explored the underlying neuroprotective mechanisms. We found that Qcn not only improved RGC survival and function from a very early stage of COHT invivo, it promoted the survival of hypoxia-treated primary cultured RGCs invitro via ameliorating mitochondrial function and preventing mitochondria-mediated apoptosis. Our findings suggest that Qcn has direct protective effects on RGCs that are independent of lowering the intraocular pressure (IOP). Qcn may be a promising therapeutic agent for improving RGC survival and function in glaucomatous neurodegeneration.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00285/fullquercetinretinal ganglion cellsglaucomaapoptosismitochondrianeuroprotection |