Isolation of Panels of Llama Single-Domain Antibody Fragments Binding All Nine Neuraminidase Subtypes of Influenza A Virus

Isolation of Panels of Llama Single-Domain Antibody Fragments Binding All Nine Neuraminidase Subtypes of Influenza A Virus

Avian influenza A virus comprises sixteen hemagglutinin (HA) and nine neuraminidase (NA) subtypes (N1–N9). To isolate llama single-domain antibody fragments (VHHs) against all N subtypes, four llamas were immunized with mixtures of influenza viruses. Selections using influenza virus yielded predomin...

Full description

Bibliographic Details
Main Authors: Guus Koch, Herman van der Burg, Willem Bartelink, Juliette C. Blokker, Sylvia B. Pritz-Verschuren, Michiel M. Harmsen
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Antibodies
Subjects:
recombinant neuraminidase
nanobody
single-domain antibody
phage display
enzymatic activity
antigenic site
Online Access:http://www.mdpi.com/2073-4468/2/2/168

Internet

http://www.mdpi.com/2073-4468/2/2/168

Similar Items