Is Carotid Body Physiological O2 Sensitivity Determined by a Unique Mitochondrial Phenotype?

The mammalian carotid body (CB) is the primary arterial chemoreceptor that responds to acute hypoxia, initiating systemic protective reflex responses that act to maintain O2 delivery to the brain and vital organs. The CB is unique in that it is stimulated at O2 levels above those that begin to impac...

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Bibliographic Details
Main Authors: Andrew P. Holmes, Clare J. Ray, Andrew M. Coney, Prem Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00562/full