Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

Abstract The active transport of glycolytic pyruvate across the inner mitochondrial membrane is thought to involve two mitochondrial pyruvate carrier subunits, MPC1 and MPC2, assembled as a 150 kDa heterotypic oligomer. Here, the recombinant production of human MPC through a co-expression strategy i...

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Bibliographic Details
Main Authors: Raghavendra Sashi Krishna Nagampalli, José Edwin Neciosup Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor Gobbi Sebinelli, Richard Marcel Bruno Moreira Girard, Carolline Fernanda Rodrigues Ascenção, Angela Maria Fala, Bianca Alves Pauletti, Sílvio Roberto Consonni, Juliana Ferreira de Oliveira, Amanda Cristina Teixeira Silva, Kleber Gomes Franchini, Adriana Franco Paes Leme, Ariel Mariano Silber, Pietro Ciancaglini, Isabel Moraes, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21740-z

Internet

https://doi.org/10.1038/s41598-018-21740-z

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