Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway

Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway

Abstract Angiogenesis is a key characteristic of asthma airway remodeling. By releasing cationic granule proteins, such as major basic protein (MBP), activated eosinophils play a prominent role in asthma, but the underlying mechanisms are still not fully understood. In this study, we demonstrated th...

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Bibliographic Details
Main Authors: Xu Chen, Manli Miao, Meng Zhou, Jie Chen, Dapeng Li, Ling Zhang, Anjiang Sun, Minglong Guan, Zixi Wang, Ping Liu, Shengquan Zhang, Xiaojun Zha, Xiaoyun Fan
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04055-2

Internet

https://doi.org/10.1038/s41419-021-04055-2

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