SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model

SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model

Abstract A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as Fos and Egr1. We employed the mouse pilocarpine mo...

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Bibliographic Details
Main Authors: Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic, Bernd Knöll
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Brain
Subjects:
SRF
Epilepsy
Pilocarpine
Immediate early gene
Mossy fiber sprouting
Fos
Online Access:http://link.springer.com/article/10.1186/s13041-017-0310-2

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http://link.springer.com/article/10.1186/s13041-017-0310-2

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