Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling

Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling

Abstract Background Long noncoding RNAs (lncRNAs) have been indicated to play critical roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 (HOXD-AS1) has recently been found to be dysregulated in several cancers. However, the expression levels, cellular localization, prec...

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Bibliographic Details
Main Authors: Min-Hui Yang, Li Zhao, Lan Wang, Wen Ou-Yang, Sha-Sha Hu, Wen-Lu Li, Mei-Ling Ai, Yi-Qing Wang, Yue Han, Ting-Ting Li, Yan-Qing Ding, Shuang Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cancer
Subjects:
lncRNA
HOXD-AS1
HOXD3
Colorectal carcinoma
PRC2
Online Access:http://link.springer.com/article/10.1186/s12943-019-0955-9

Internet

http://link.springer.com/article/10.1186/s12943-019-0955-9

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