Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location

Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location

CD4 T cell memory is fundamental for long-lasting immunity and effective secondary responses following infection or vaccination. We have previously found that memory CD4 T cells specific for systemic antigens preferentially reside in the bone marrow (BM) and arise from splenic CD49b+T-bet+ CD4 T cel...

Full description

Bibliographic Details
Main Authors: Jana Sarkander, Shintaro Hojyo, Mathias Mursell, Yuzuru Yamasaki, Tsung-Yen Wu, Damon J. Tumes, Kosuke Miyauchi, Cam Loan Tran, Jinfang Zhu, Max Löhning, Andreas Hutloff, Mir-Farzin Mashreghi, Masato Kubo, Andreas Radbruch, Koji Tokoyoda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
CD4 T cells
memory
bone marrow
cell division
migration
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03113/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03113/full

Similar Items