Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs. Akt phosphorylation transduces adhesion-mediated regu...

Full description

Bibliographic Details
Main Authors: Junaid Afzal, MBBS, MS, Angel Chan, MD PhD, Mehmet Fatih Karakas, MD, Kirubel Woldemichael, BS, Styliani Vakrou, MD, Yufan Guan, MD, Jeffrey Rathmell, PhD, Richard Wahl, MD, Martin Pomper, MD, PhD, D. Brian Foster, PhD, Miguel A. Aon, PhD, Benjamin Tsui, PhD, Brian O’Rourke, PhD, M. Roselle Abraham, MD
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:JACC: Basic to Translational Science
Subjects:
cardiosphere-derived cells (CDCs)
glycolysis
metabolism
oxidative phosphorylation (OxPhos)
sodium-iodide symporter (NIS)
SPECT imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1730219X

Internet

http://www.sciencedirect.com/science/article/pii/S2452302X1730219X

Similar Items