Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status
Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs. Akt phosphorylation transduces adhesion-mediated regu...
Main Authors: | Junaid Afzal, MBBS, MS, Angel Chan, MD PhD, Mehmet Fatih Karakas, MD, Kirubel Woldemichael, BS, Styliani Vakrou, MD, Yufan Guan, MD, Jeffrey Rathmell, PhD, Richard Wahl, MD, Martin Pomper, MD, PhD, D. Brian Foster, PhD, Miguel A. Aon, PhD, Benjamin Tsui, PhD, Brian O’Rourke, PhD, M. Roselle Abraham, MD |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-10-01
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Series: | JACC: Basic to Translational Science |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X1730219X |
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