Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients

Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients

Abstract Background The development of Systemic lupus erythematosus (SLE) has been associated with the balance of Th17 and Treg cells. IL-2 and rapamycin can influence the populations of both Th17 and Treg cells. However, it is unclear whether low dose of IL-2 and rapamycin can relieve the symptoms...

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Bibliographic Details
Main Authors: Chunmiao Zhao, Yanfang Chu, Zhaoyun Liang, Bingying Zhang, Xuxia Wang, Xiaona Jing, Meihua Hao, Yiqi Wang, Jia An, Xingzhe Zhang, Liguang Sun, Junwei Chen
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Immunology
Subjects:
Systemic lupus erythematosus
IL-2
Rapamycin
Th17 cells
Treg cells
Online Access:http://link.springer.com/article/10.1186/s12865-019-0305-0

Internet

http://link.springer.com/article/10.1186/s12865-019-0305-0

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