Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

Part I. Basic Principles. TB vaccines cannot prevent establishment of the infection. They can only prevent an early pulmonary tubercle from developing into clinical disease. A more effective new vaccine should optimize both cell-mediated immunity (CMI) and delayed-type hypersensitivity (DTH) better...

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Bibliographic Details
Main Authors: Bappaditya Dey, Arthur M. Dannenberg
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Vaccines
Subjects:
tuberculosis
TB perspectives
TB pathogenesis
TB immunology
TB vaccines
delayed-type hypersensitivity
cell-mediated immunity
TB in rabbits
TB in mice
TB in guinea pigs
TB in humans
TB vaccine clinical trials
TB latency
TB reactivation
Online Access:http://www.mdpi.com/2076-393X/1/1/58

Internet

http://www.mdpi.com/2076-393X/1/1/58

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