Immunosenescence profile and expression of the aging biomarker (p16 INK4a ) in testicular cancer survivors treated with chemotherapy

Immunosenescence profile and expression of the aging biomarker (p16 INK4a ) in testicular cancer survivors treated with chemotherapy

Abstract Background Cytotoxic chemotherapy can cure advanced germ cell tumors. Nevertheless, cancer treatment may induce cellular senescence and accelerate molecular aging. The aging process implies an increase of cells expressing p16 INK4a and changes in lymphocyte subpopulations. Our aim was to st...

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Bibliographic Details
Main Authors: Maria T. Bourlon, Hugo E. Velazquez, Juan Hinojosa, Luis Orozco, Ricardo Rios-Corzo, Guadalupe Lima, Luis Llorente, Diego F. Hernandez-Ramirez, Francisco J. Valentin-Cortez, Irene Medina-Rangel, Yemil Atisha-Fregoso
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
Testicular cancer survivors
Germ cell tumors
Immunosenescence
Premature aging
p16INK4a
Testicular cancer
Online Access:http://link.springer.com/article/10.1186/s12885-020-07383-2

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http://link.springer.com/article/10.1186/s12885-020-07383-2

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