Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure

Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure

Abstract Aims Inhibition of neprilysin and angiotensin II receptor by sacubitril/valsartan (Val) (LCZ696) reduces mortality in heart failure (HF) patients compared with sole inhibition of renin–angiotensin system. Beneficial effects of increased natriuretic peptide levels upon neprilysin inhibition...

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Bibliographic Details
Main Authors: Jörg Eiringhaus, Christoph M. Wünsche, Petros Tirilomis, Jonas Herting, Nadja Bork, Viacheslav O. Nikolaev, Gerd Hasenfuss, Samuel Sossalla, Thomas H. Fischer
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:ESC Heart Failure
Subjects:
Heart failure
Entresto
Neprilysin inhibition
Ca cycling
SR Ca leak
Arrhythmia
Online Access:https://doi.org/10.1002/ehf2.12918

Internet

https://doi.org/10.1002/ehf2.12918

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