Nuclear Aurora kinase A triggers programmed death‐ligand 1‐mediated immune suppression by activating MYC transcription in triple‐negative breast cancer

Nuclear Aurora kinase A triggers programmed death‐ligand 1‐mediated immune suppression by activating MYC transcription in triple‐negative breast cancer

Abstract Background Increasing studies have reported that oncogenes regulate components of the immune system, suggesting that this is a mechanism for tumorigenesis. Aurora kinase A (AURKA), a serine/threonine kinase, is involved in cell mitosis and is essential for tumor cell proliferation, metastas...

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Bibliographic Details
Main Authors: Shulan Sun, Wei Zhou, Xiaoxi Li, Fei Peng, Min Yan, Yajing Zhan, Fan An, Xiaoyan Li, Yunyong Liu, Quentin Liu, Haozhe Piao
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Cancer Communications
Subjects:
Aurora kinase A
immune evasion
immunotherapy
MYC
programmed death‐ligand 1
triple‐negative breast cancer
Online Access:https://doi.org/10.1002/cac2.12190

Internet

https://doi.org/10.1002/cac2.12190

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