Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling

Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling

Avasimibe is a bioavailable acetyl-CoA acetyltransferase (ACAT) inhibitor and shows a good antitumor effect in various human solid tumors, but its therapeutic value in cholangiocarcinoma (CCA) and underlying mechanisms are largely unknown. In the study, we proved that avasimibe retard cell prolifera...

Full description

Bibliographic Details
Main Authors: Yunshu Gao, Dongyun Xu, Hongwei Li, Jiahua Xu, Yating Pan, Xinyi Liao, Jianxin Qian, Yi Hu, Guanzhen Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
cholangiocarcinoma
FoxM1
AKR1C1
avasimibe
progression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.677678/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.677678/full

Similar Items