The Aberrant Expression of the Mesenchymal Variant of FGFR2 in the Epithelial Context Inhibits Autophagy

The Aberrant Expression of the Mesenchymal Variant of FGFR2 in the Epithelial Context Inhibits Autophagy

Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation, epithelial mesenchymal transition (EMT) and tu...

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Bibliographic Details
Main Authors: Monica Nanni, Danilo Ranieri, Flavia Persechino, Maria Rosaria Torrisi, Francesca Belleudi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
FGFR2c
autophagy
keratinocyte
MTOR
JNK1
Online Access:https://www.mdpi.com/2073-4409/8/7/653

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https://www.mdpi.com/2073-4409/8/7/653

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