Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut.

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut.

Interactions between commensal fungi and gut immune system are critical for establishing colonic homeostasis. Here we found that mice deficient in Dectin-3 (Clec4d-/-), a C-type lectin receptor that senses fungal infection, were more susceptible to dextran sodium sulfate (DSS)-induced colitis compar...

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Bibliographic Details
Main Authors: Tingting Wang, Deng Pan, Zhicheng Zhou, Yun You, Changying Jiang, Xueqiang Zhao, Xin Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4900642?pdf=render

Internet

http://europepmc.org/articles/PMC4900642?pdf=render

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