Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.

Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.

A new paradigm of mucosal vaccination against HIV infection has been investigated in the macaque model. A vaccine consisting of inactivated SIVmac239 particles together with a living bacterial adjuvant (either the Calmette & Guerin bacillus, lactobacillus plantarum or Lactobacillus rhamnosus) wa...

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Bibliographic Details
Main Authors: Jean Marie eAndrieu, song echen, Chunhui eLAI, weizhong eguo, Wei eLu
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
BCG
HIV vaccine
lactobacilli
inactivated SIV
bacterial adjuvants
SIV replication
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00297/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00297/full

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