Neutrophils from severe asthmatic patients induce epithelial to mesenchymal transition in healthy bronchial epithelial cells

Neutrophils from severe asthmatic patients induce epithelial to mesenchymal transition in healthy bronchial epithelial cells

Abstract Background Asthma is a heterogenous disease characterized by chronic inflammation and airway remodeling. An increase in the severity of airway remodeling is associated with a more severe form of asthma. There is increasing interest in the epithelial to mesenchymal transition process and mec...

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Bibliographic Details
Main Authors: Alexandre Haddad, Mellissa Gaudet, Maria Plesa, Zoulfia Allakhverdi, Andrea K. Mogas, Severine Audusseau, Carolyn J. Baglole, David H. Eidelman, Ronald Olivenstein, Mara S. Ludwig, Qutayba Hamid
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Respiratory Research
Subjects:
Epithelial-mesenchymal transition
Airway remodeling
Severe asthma
Neutrophils
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s12931-019-1186-8

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http://link.springer.com/article/10.1186/s12931-019-1186-8

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