Epigenetic Inactivation of the Tumor Suppressor <i>IRX1</i> Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis

Epigenetic Inactivation of the Tumor Suppressor <i>IRX1</i> Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis

<i>Iroquois homeobox</i> (IRX) encodes members of homeodomain containing genes which are involved in development and differentiation. Since it has been reported that the <i>IRX1</i> gene is localized in a lung cancer susceptibility locus, the epigenetic regulation and functio...

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Bibliographic Details
Main Authors: Miriam M. Küster, Marc A. Schneider, Antje M. Richter, Sarah Richtmann, Hauke Winter, Mark Kriegsmann, Soni S. Pullamsetti, Thorsten Stiewe, Rajkumar Savai, Thomas Muley, Reinhard H. Dammann
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
IRX
DNA methylation
epigenetic
lung cancer
adenocarcinoma
apoptosis
Online Access:https://www.mdpi.com/2072-6694/12/12/3528

Internet

https://www.mdpi.com/2072-6694/12/12/3528

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