Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell Resistance

Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell Resistance

Somatic gene mutations play a critical role in immune evasion by tumors. However, there is limited information on genes that confer immunotherapy resistance in melanoma. To answer this question, we established a whole-genome knockout B16/ovalbumin cell line by clustered regularly interspaced short p...

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Bibliographic Details
Main Authors: Ping Han, Qiang Dai, Lilv Fan, Hao Lin, Xiaoqing Zhang, Fanlin Li, Xuanming Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
JAK1 deficiency
CRISPR/Cas9
T-cell resistance
immunotherapy
melanoma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00251/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00251/full

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