BTG1 is required to maintain the pool of stem and progenitor cells of dentate gyrus and subventricular zone

BTG1 is required to maintain the pool of stem and progenitor cells of dentate gyrus and subventricular zone

Btg1 belongs to a family of cell cycle inhibitory genes. We observed that Btg1 is highly expressed in adult neurogenic niches, i.e., the dentate gyrus and subventricular zone (SVZ). Thus, we generated Btg1 knockout mice to analyze the role of Btg1 in the process of generation of adult new neurons.Ab...

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Bibliographic Details
Main Authors: Stefano eFarioli-Vecchioli, Laura eMicheli, Daniele eSaraulli, Manuela eCeccarelli, Sara eCannas, Raffaella eScardigli, Luca eLeonardi, Irene eCinà, Marco eCostanzi, Maria Teresa eCiotti, Pedro eMoreira, Jean-Pierre eRouault, Vincenzo eCestari, Felice eTirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Neuroscience
Subjects:
Neural Stem Cells
knock out mice
differentiation
proliferation
learning and memory
BTG family
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00124/full

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http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00124/full

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