Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy

Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy

Lysosomal accumulation of sunitinib has been suggested as an underlying mechanism of resistance. Here, we investigated if photochemical internalization (PCI), a technology for cytosolic release of drugs entrapped in endosomes and lysosomes, would activate lysosomal sequestered sunitinib. By super-re...

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Bibliographic Details
Main Authors: Judith Jing Wen Wong, Maria Brandal Berstad, Ane Sofie Viset Fremstedal, Kristian Berg, Sebastian Patzke, Vigdis Sørensen, Qian Peng, Pål Kristian Selbo, Anette Weyergang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
sunitinib
photochemical internalization
photodynamic therapy
lysosomal sequestration
cytosolic release
photochemical release
sunitinib resistance
Online Access:https://www.mdpi.com/2072-6694/12/2/417

Internet

https://www.mdpi.com/2072-6694/12/2/417

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