The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer

The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer

Abstract Accumulating evidence suggests that dysregulation of transcriptional enhancers plays a significant role in cancer pathogenesis. Herein, we performed a genome-wide discovery of enhancer elements in colorectal cancer (CRC). We identified PVT1 locus as a previously unrecognized transcriptional...

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Bibliographic Details
Main Authors: Kunitoshi Shigeyasu, Shusuke Toden, Tsuyoshi Ozawa, Takatoshi Matsuyama, Takeshi Nagasaka, Toshiaki Ishikawa, Debashis Sahoo, Pradipta Ghosh, Hiroyuki Uetake, Toshiyoshi Fujiwara, Ajay Goel
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Cancer
Subjects:
PVT1
MYC
Enhancer
Epigenetic
Prognostic marker
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12943-020-01277-4

Internet

http://link.springer.com/article/10.1186/s12943-020-01277-4

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