Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target

Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target

Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues of various proteins. Despite extensive research on ebselen, its target molecules and mechanism of action remains less understood. We performed bioch...

Full description

Bibliographic Details
Main Authors: Gajendra Kumar Azad, Vikash Singh, Papita Mandal, Prabhat Singh, Upendarrao Golla, Shivani Baranwal, Sakshi Chauhan, Raghuvir S. Tomar
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Ebselen
ROS levels
Mitochondrial membrane potential
Glutamate dehydrogenase
Histone clipping
Yeast sporulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000035

Internet

http://www.sciencedirect.com/science/article/pii/S2211546314000035

Similar Items