Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia

Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia

Abstract Background Hypoxic tumor microenvironment (TME) promotes tumor metastasis and drug resistance, leading to low efficiency of cancer chemotherapy. The development of targeted agents or multi-target therapies regulating hypoxic microenvironment is an important approach to overcome drug resista...

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Bibliographic Details
Main Authors: Yan Chen, Lei Fang, Weixin Zhou, Jinghan Chang, Xiaojuan Zhang, Chuanchuan He, Chen Chen, Ruicong Yan, Yakai Yan, Yao Lu, Chuanrui Xu, Guangya Xiang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Nanobiotechnology
Subjects:
Hypoxia
Drug resistance
Metastasis
HIF-1α
Cisplatin
Nitric oxide
Online Access:https://doi.org/10.1186/s12951-021-00989-z

Internet

https://doi.org/10.1186/s12951-021-00989-z

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