Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia–ischemia in mice with neuronal Fyn overexpression

Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia–ischemia in mice with neuronal Fyn overexpression

The Src family kinases (SFKs) Src and Fyn are implicated in hypoxic–ischemic (HI) injury in the developing brain. However, it is unclear how these particular SFKs contribute to brain injury. Using neuron-specific Fyn overexpressing (OE) mice, we investigated the role of neuronal Fyn in neonatal brai...

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Bibliographic Details
Main Authors: Renatta Knox, Chong Zhao, Dario Miguel-Perez, Steven Wang, Jinwei Yuan, Donna Ferriero, Xiangning Jiang
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Fyn
Neonatal brain
Hypoxia–ischemia
NR2B
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003610

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http://www.sciencedirect.com/science/article/pii/S0969996112003610

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