Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Abstract Background HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune diseases. Rheumatoid arthritis (RA) is a chronic autoimmune disorder for...

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Bibliographic Details
Main Authors: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen, Vivianne Malmström
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Immunology
Subjects:
Autoimmune disease
Autoreactive CD4+ T lymphocytes
Multi-MHC class II tetramer assay
Citrullination
Online Access:http://link.springer.com/article/10.1186/s12865-020-00357-w

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http://link.springer.com/article/10.1186/s12865-020-00357-w

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