Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Mouse models of Alzheimer’s disease (AD) exhibit marked differences in life expectancy depending on their genotype and sex. The assessment of frailty could provide a measure of healthspan to facilitate comparisons between different AD models. We used a validated mouse frailty index (FI) assessment t...

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Bibliographic Details
Main Authors: Alice E. Kane, Sooyoun Shin, Aimee A. Wong, Emre Fertan, Natalia S. Faustova, Susan E. Howlett, Richard E. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
frailty
sex differences
deficit index
frailty index
deficit accumulation
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00172/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00172/full

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