Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response

Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response

Abstract Background Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 oncoproteins, still represents the fourth tumor and the second cause of death among women. Cell replication fidelity is the result of the host DNA damage response (DDR). Unlike many DNA viruse...

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Bibliographic Details
Main Authors: Diletta Francesca Squarzanti, Rita Sorrentino, Manuela Miriam Landini, Andrea Chiesa, Sabrina Pinato, Francesca Rocchio, Martina Mattii, Lorenza Penengo, Barbara Azzimonti
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Virology Journal
Subjects:
High-risk Human Papillomavirus
Cancer
DNA damage response
E6-associated protein
Double-strand break
In vitro 3D epithelial model
Online Access:http://link.springer.com/article/10.1186/s12985-018-1086-4

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http://link.springer.com/article/10.1186/s12985-018-1086-4

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