Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice

Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice

Background: Podocyte foot process effacement is a key histologic finding in proteinuric kidney disease. We previously showed that 3-week old CD2AP-deficient mice have significant proteinuria, glomerular hypertrophy and mesangial expansion. The goal of this study is to use morphometry to establish th...

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Bibliographic Details
Main Authors: John M. Basgen, Jenny S. Wong, Justina Ray, Susanne B. Nicholas, Kirk N. Campbell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
CD2AP deficient mice
podocyte foot process effacement
albuminuria
kidney morphometry
glomerular volume
Cavalieri Principle
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.745319/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.745319/full

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