Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60).

Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60).

Osteosarcoma is one of the most malignant tumors of childhood and adolescence that is often resistant to standard chemo- and radio-therapy. Geldanamycin and geldanamycin analogs have been recently studied as potential anticancer agents for osteosarcoma treatment. Here, for the first time, we have pr...

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Bibliographic Details
Main Authors: Magdalena Gorska, Antonella Marino Gammazza, Michal Aleksander Zmijewski, Claudia Campanella, Francesco Cappello, Tomasz Wasiewicz, Alicja Kuban-Jankowska, Agnieszka Daca, Alicja Sielicka, Urszula Popowska, Narcyz Knap, Jakub Antoniewicz, Takashi Wakabayashi, Michal Wozniak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756027?pdf=render

Internet

http://europepmc.org/articles/PMC3756027?pdf=render

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