IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

IgG4 subclass antibodies are expressed in alternative Th2 environments featuring high IL-10 expression, including several solid tumors such as melanoma. To induce tolerance, allergen immunotherapy mediates antibody class switching from pro-inflammatory IgE to anti-inflammatory IgG4. We previously re...

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Bibliographic Details
Main Authors: Galateja Jordakieva, Rodolfo Bianchini, Daniel Reichhold, Jakob Piehslinger, Alina Groschopf, Sebastian A. Jensen, Ettore Mearini, Giuseppe Nocentini, Richard Crevenna, Gerhard J. Zlabinger, Sophia N. Karagiannis, Alexander Klaus, Erika Jensen-Jarolim
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
igg4
ige
tumor-associated macrophages
m2b
allergooncology
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1880687

Internet

http://dx.doi.org/10.1080/2162402X.2021.1880687

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