Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways

Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways

Abstract Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe NAFLD fibrosis have been limited. We used the Hum...

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Bibliographic Details
Main Authors: Glenn S. Gerhard, Ivana Malenica, Lorida Llaci, Xin Chu, Anthony T. Petrick, Christopher D. Still, Johanna K. DiStefano
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Clinical Epigenetics
Subjects:
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Liver fibrosis
DNA methylation
Epigenetics
Severe obesity
Online Access:http://link.springer.com/article/10.1186/s13148-018-0525-9

Internet

http://link.springer.com/article/10.1186/s13148-018-0525-9

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