Identification of New Antifungal Compounds Targeting Thioredoxin Reductase of Paracoccidioides Genus.

The prevalence of invasive fungal infections worldwide has increased in the last decades. The development of specific drugs targeting pathogenic fungi without producing collateral damage to mammalian cells is a daunting pharmacological challenge. Indeed, many of the toxicities and drug interactions...

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Bibliographic Details
Main Authors: Ana Karina Rodrigues Abadio, Erika Seki Kioshima, Vincent Leroux, Natalia Florêncio Martins, Bernard Maigret, Maria Sueli Soares Felipe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4646694?pdf=render