Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography

Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography

Combining tomography with electron microscopy (EM) produces images at definition sufficient to visualize individual protein molecules or molecular complexes in intact neurons. When freeze-substituted hippocampal cultures in plastic sections are imaged by EM tomography, detailed structures emerging f...

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Bibliographic Details
Main Authors: Xiaobing Chen, Christine Winters, Virginia Crocker, Michael Lazarou, Alioscka A. Sousa, Richard D. Leapman, Thomas S. Reese
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroanatomy
Subjects:
PSD-95
miniSOG
EM tomography
photoconversion
diffusion
labeling
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2018.00107/full

Internet

https://www.frontiersin.org/article/10.3389/fnana.2018.00107/full

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