Growth-dependent recombinant product formation kinetics can be reproduced through engineering of glucose transport and is prone to phenotypic heterogeneity

Growth-dependent recombinant product formation kinetics can be reproduced through engineering of glucose transport and is prone to phenotypic heterogeneity

Abstract Background Escherichia coli W3110 and a group of six isogenic derivatives, each displaying distinct specific rates of glucose consumption were characterized to determine levels of GFP production and population heterogeneity. These strains have single or combinatory deletions in genes encodi...

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Bibliographic Details
Main Authors: Juan Carlos Fragoso-Jiménez, Jonathan Baert, Thai Minh Nguyen, Wenzheng Liu, Hosni Sassi, Frédéric Goormaghtigh, Laurence Van Melderen, Paul Gaytán, Georgina Hernández-Chávez, Alfredo Martinez, Frank Delvigne, Guillermo Gosset
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Microbial Cell Factories
Subjects:
Single cell
Metabolic engineering
Filamentation
Flow cytometry
Microfluidic imaging
Online Access:http://link.springer.com/article/10.1186/s12934-019-1073-5

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http://link.springer.com/article/10.1186/s12934-019-1073-5

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