mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse

mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse

Fast and sustained antidepressant effects of ketamine identified the mammalian target of rapamycin (mTOR) signaling pathway as the main modulator of its antidepressive effects. Thus, mTOR signaling has become integral for the preclinical evaluation of novel compounds to treat depression. However, ca...

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Bibliographic Details
Main Authors: Emilio Garro-Martínez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Verónica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Analía Bortolozzi, Fuencisla Pilar-Cuéllar
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
mTOR
infralimbic cortex
behavioral despair
BDNF
neurotransmitter
Online Access:https://www.mdpi.com/1422-0067/22/16/8671

Internet

https://www.mdpi.com/1422-0067/22/16/8671

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