The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector

The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector

Abstract Background Agonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly; these differences are particularly critical for immunization with non-replicating adenovirus vectors (rAds) based vaccin...

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Bibliographic Details
Main Authors: Ekaterina Lebedeva, Alexander Bagaev, Alexey Pichugin, Marina Chulkina, Andrei Lysenko, Irina Tutykhina, Maxim Shmarov, Denis Logunov, Boris Naroditsky, Ravshan Ataullakhanov
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Immunology
Subjects:
Toll-like receptors
Agonists
Adjuvants
Immunization
Recombinant non-replicating adenoviral vector
Expression of transgenes
Online Access:http://link.springer.com/article/10.1186/s12865-018-0264-x

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http://link.springer.com/article/10.1186/s12865-018-0264-x

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