Selective sterol accumulation in ABCG5/ABCG8-deficient mice

Selective sterol accumulation in ABCG5/ABCG8-deficient mice

The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols. Mutations in either gene cause sitosterolemia, a rare recessive disease in which plasma and tissue levels of several neutral sterols are increased to varying degr...

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Bibliographic Details
Main Authors: Liqing Yu, Klaus von Bergmann, Dieter Lutjohann, Helen H. Hobbs, Jonathan C. Cohen
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Journal of Lipid Research
Subjects:
plant sterols
biliary secretion
brain
sitosterolemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319027

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http://www.sciencedirect.com/science/article/pii/S0022227520319027

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