The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

<p>Abstract</p> <p>Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered...

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Bibliographic Details
Main Authors: Saavedra Harold I, Adon Arsene M, Harrison Mary K
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/6/1/2