The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

<p>Abstract</p> <p>Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered...

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Main Authors: Saavedra Harold I, Adon Arsene M, Harrison Mary K
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/6/1/2
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spelling doaj-f8451bc19312442eb2b518c156edf5cd2020-11-24T22:06:38ZengBMCCell Division1747-10282011-01-0161210.1186/1747-1028-6-2The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplificationSaavedra Harold IAdon Arsene MHarrison Mary K<p>Abstract</p> <p>Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.</p> http://www.celldiv.com/content/6/1/2
collection DOAJ
language English
format Article
sources DOAJ
author Saavedra Harold I
Adon Arsene M
Harrison Mary K
spellingShingle Saavedra Harold I
Adon Arsene M
Harrison Mary K
The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
Cell Division
author_facet Saavedra Harold I
Adon Arsene M
Harrison Mary K
author_sort Saavedra Harold I
title The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
title_short The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
title_full The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
title_fullStr The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
title_full_unstemmed The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
title_sort g<sub>1 </sub>phase cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
publisher BMC
series Cell Division
issn 1747-1028
publishDate 2011-01-01
description <p>Abstract</p> <p>Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.</p>
url http://www.celldiv.com/content/6/1/2
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