High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells

High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells

Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in the uptake of a variety of molecules, such as apoE, α2-macroglobulin, and the amyloid β peptide (Aβ), for either transcellular transport, protein trafficking or lysosomal degradation. The LRP1 gene can be...

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Bibliographic Details
Main Authors: Alejandro N. Rondón-Ortiz, Christian L. Lino Cardenas, Jimena Martínez-Málaga, Ana L. Gonzales-Urday, Kuljeet S. Gugnani, Mark Böhlke, Timothy J. Maher, Alejandro J. Pino-Figueroa
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
LRP1
rosiglitazone
PPARγ
protein degradation
lysosomal degradation
bafilomycin A1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00772/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00772/full

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