Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerance to benzo[a]pyrene in S. cerevisiae

Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerance to benzo[a]pyrene in S. cerevisiae

Benzo[a]pyrene (BaP) is a ubiquitous, potent, and complete carcinogen resulting from incomplete organic combustion. BaP can form DNA adducts but other mechanisms may play a role in toxicity. We used a functional toxicology approach in S. cerevisiae to assess the genetic requirements for cellular r...

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Bibliographic Details
Main Authors: Sean Timothy Francis O'Connor, Jiaqi eLan, Matthew eNorth, Alexandre eLoguinov, Luoping eZhang, Martyn T Smith, April eGu, Chris eVulpe
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Genetics
Subjects:
stress
ontology
yeast
Toxicity
Resistance
Sensitivity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00316/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00316/full

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