HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AM...

Full description

Bibliographic Details
Main Authors: Mandy Beyer, Annette Romanski, Al-Hassan M. Mustafa, Miriam Pons, Iris Büchler, Anja Vogel, Andrea Pautz, Andreas Sellmer, Günter Schneider, Gesine Bug, Oliver H. Krämer
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
aml
β-catenin
hdac
hdaci
indomethacin
molecular marker
myc
wt1
Online Access:https://www.mdpi.com/2072-6694/11/10/1436

Internet

https://www.mdpi.com/2072-6694/11/10/1436

Similar Items