Extracellular Environment Contribution to Astrogliosis – Lessons learned from a Tissue Engineered 3D Model of the Glial Scar

Glial scars are widely seen as a (bio)mechanical barrier to central nervous system regeneration. Due to the lack of a screening platform, which could allow in-vitro testing of several variables simultaneously, up to now no comprehensive study has addressed and clarified how different lesion microenv...

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Bibliographic Details
Main Authors: Daniela Nogueira Rocha, José eFerraz-Nogueira, Cristina Carvalho Barrias, João Bettencourt Relvas, Ana Paula ePêgo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00377/full