The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions, HMGCR is ubiquitinated and degraded, but the ident...

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Bibliographic Details
Main Authors: Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
RNF145
gp78
HMGCR
cholesterol
ER associated degradation
E3 ubiquitin ligase
Online Access:https://elifesciences.org/articles/40009

Internet

https://elifesciences.org/articles/40009

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